The Potential of Taxus sumatrana as a Candidate for Cancer Therapy

Main Article Content

Desi Eka Putri
Almahdy Almahdy
Dachriyanus Hamidi
Fatma Sri Wahyuni

Abstract

This article aims to review the literature on studies supporting using Taxus sumatrana (Miq.) de Laub (Cemara Sumatra) as a cancer treatment. The method involved a literature review using the keywords "Taxus sumatrana" and chemical compound or pharmacological activity. There are no reports of pharmacological activity related to cancer from extracts or parts of the T. sumatrana plant. Despite a lack of scientific evidence supporting its anticancer activity, T. sumatrana is widely used to treat cancer traditionally. So, further research is needed to validate using T. sumatrana as a cancer treatment. Pharmacodynamic studies are necessary to demonstrate its mechanism of action. Additionally, toxicity studies are needed to determine the safety, ensuring no toxic effects on normal cells. Further research is also required to evaluate the effectiveness of T. sumatrana in clinical cancer treatment. In conclusion, T. sumatrana promises to be a natural medicine for cancer treatment. However, its validated use as a cancer treatment requires adequate supporting data scientifically.

Article Details

How to Cite
Putri, D. E., Almahdy, A. ., Hamidi, D. ., & Wahyuni, F. S. . (2023). The Potential of Taxus sumatrana as a Candidate for Cancer Therapy . The Journal of Food and Medicinal Plants, 4(1), 1-7. https://doi.org/10.25077/jfmp.4.1.1-7.2023
Section
Literature review
Author Biographies

Almahdy Almahdy, Universitas Andalas

Faculty of Pharmacy

Dachriyanus Hamidi, Universitas Andalas

Faculty of Pharmacy

Fatma Sri Wahyuni, Universitas Andalas

Faculty of Pharmacy

References

De Laubenfels. 1988. Coniferales: Taxaceae. Flora Malesiana, 10(1), 347–351.

Frianto, D. 2016. The distribution pattern and the density potential of Taxus sumatrana in Mount Tujuh, Kerinci District, Jambi. Prosiding Seminar Nasional Masyarakat Biodiversity Indonesia 2(1), 12–15. https://doi.org/10.13057/psnmbi/m020103

Frianto, D., Novriyanti, E. 2017. Eksplorasi potensi Taxus sumatrana di Gunung Kerinci, Sumatera. Prosiding Seminar Nasional Masyarakat Biodiversity Indonesia, 3(3), 471-475. https://doi.org/10.13057/psnmbi/m030329

Hidayat, A., Hendalastuti, H., Subiakto, R.A. 2014. Mutiara Terpendam dari Zamrud. 1st ed. Forda Press, Bogor.

Kitagawa, I., Mahmud, T., Kobayashi, M., Roemantyo, H., Shibuya, H. 1995. Taxol and its Related Taxoids from the Needles of Taxus Sumatrana. Chemical and Pharmaceutical Bulletin, 43(2), 365-367. https://doi.org/10.1248/cpb.43.365

Kumar, S., Mahdi, H., Bryant, C., Shah, J.P., Garg, G., Munkarah, A. 2010. Clinical trials and progress with paclitaxel in ovarian cancer. International Journal of Women’s Health, 2(1), 411–427. https://doi.org/10.2147/IJWH.S7012

Kuo, W.L., Chen, F.C., Chen, K.J., Chen, J.J. 2015. Taxusumatrin, a new taxoid from the stem bark of Taxus sumatrana. Chemistry of Natural Compounds, 51(3). https://doi.org/10.1007/s10600-015-1308-6

Liebmann, J.E., Cook, J.A., Lipschultz, C., Teague, D., Fisher, J., Mitchell, J.B. 1993. Cytotoxic studies of paclitaxel (Taxol®) in human tumour cell lines. British Journal of Cancer, 68(6), 1104–1109. https://doi.org/10.1038/bjc.1993.488

Luh, L.J., Abd El-Razek, M.H., Liaw, C.C., Chen, T.A., Lin, Y.S., Kuo, Y.H., Chien, C.T, Shen, Y.C. 2009. Tri- and bicyclic taxoids from the Taiwanese Yew Taxus sumatrana. Helvetica Chimica Acta, 92(7), 1349–1358. https://doi.org/10.1002/hlca.200900022

MENLHK. 2018. Permen-Jenis-Satwa-dan-Tumbuhan-Dilindungi. Menteri Lingkungan Hidup Dan Kehutanan Republik Indonesia, 1–30.

Muhaimin, M. 2017. Taxus sumatrana (Miq.) de Laub. Obat Anti Kanker Masa Depan. Warta Kebun Raya, 14, 11–20.

Perez, E.A. 1998. Paclitaxel in Breast Cancer. The Oncologist, 3(6), 373–389. https://doi.org/10.1634/theoncologist.3-6-373

Ramalingam, S., Belani, C.P. 2004. Paclitaxel for non-small cell lung cancer. Expert Opinion on Pharmacotherapy, 5(8), 1771–1780. https://doi.org/10.1517/14656566.5.8.1771

Régnier-Rosencher, E., Guillot, B., Dupin, N. 2013. Treatments for classic Kaposi sarcoma: A systematic review of the literature. Journal of the American Academy of Dermatology, 68(2), 313–331. https://doi.org/10.1016/j.jaad.2012.04.018

Saif, M.W., Podoltsev, N.A., Rubin, M.S., Figueroa, J.A., Lee, M.Y., Kwon, J., Rowen, E., Yu, J., Kerr, R.O. 2010. Phase II clinical trial of paclitaxel loaded polymeric micelle in patients with advanced pancreatic cancer. Cancer Investigation, 28(2), 186–194. https://doi.org/10.3109/07357900903179591

Sato, K., Inoue, K., Saito, T., Kai, T., Mihara, H., Okubo, K., Koh, J., Mochizuki, H., Tabei, T. 2003. Multicenter phase II trial of weekly paclitaxel for advanced or metastatic breast cancer: The Saitama Breast Cancer Clinical Study Group (SBCCSG-01). Japanese Journal of Clinical Oncology, 33(8), 371–376. https://doi.org/10.1093/jjco/hyg075

Shen, Y.C., Cheng, K.C., Lin, Y.C., Cheng, Y. Bin, Khalil, A.T., Guh, J.H., Chien, C.T, Teng, C.M., Chang, Y.T. 2005. Three new taxane diterpenoids from Taxus sumatrana. Journal of Natural Products, 68(1), 90-93. https://doi.org/10.1021/np040132w

Shen, Y.C., Hsu, S.M., Lin, Y.S., Cheng, K.C., Chien, C.T, Chou, C.H., Cheng, Y.B. 2005. New bicyclic taxane diterpenoids from Taxus sumatrana. Chemical and Pharmaceutical Bulletin, 53(7), 808-810. https://doi.org/10.1248/cpb.53.808

Shen, Y.C., Lin, Y.S., Cheng, Y.B, Cheng, K.C., Khalil, A.T., Kuo, Y.H., Chien, C.T, Lin, Y.C. 2005. Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester. Tetrahedron, 61(5), 1345-1352. https://doi.org/10.1016/j.tet.2004.10.110

Shen, Y.C., Lin, Y.S., Hsu, S.M., Khalil, A.T., Wang, S.S., Chien, C.T, Kuo, Y.H., Chou, C.H. 2007. Tasumatrols P-T, five new taxoids from Taxus sumatrana. Helvetica Chimica Acta, 90(7), 1319-1329. https://doi.org/10.1002/hlca.200790133

Shen, Y.C., Pan, Y.L., Lo, K.L., Wang, S.S., Chang, Y.T., Wang, L.T., Lin, Y.C. 2003. New taxane diterpenoids from Taiwanese Taxus sumatrana. Chemical and Pharmaceutical Bulletin, 51(7), 867-869. https://doi.org/10.1248/cpb.51.867

Shen, Y.C., Wang, S.S., Chien, C.T, Kuo, Y.H., Khalil, A.T. 2008. Tasumatrols U-Z, taxane diterpene esters from Taxus sumatrana. Journal of Natural Products, 71(4), 576–580. https://doi.org/10.1021/np078016r

Shen, Y.C., Wang, S.S., Pan, Y.L., Lo, K.L., Chakraborty, R., Chien, C.T, Kuo, Y.H., Lin, Y.C. 2002. New taxane diterpenoids from the leaves and twigs of Taxus sumatrana. Journal of Natural Products, 65(12), 1848–1852. https://doi.org/10.1021/np0202273

Spjut, R.W. 2007. Taxonomy and nomenclature of Taxus (Taxaceae). Journal of the Botanical Research Institute of Texas, 1(1), 203-289.

Sudarmin, S., Diliarosta, S., Pujiastuti, R.S.E., Jumini, S., Prasetya, A.T. 2020. The instructional design of ethnoscience-based inquiry learning for scientific explanation about Taxus sumatrana as cancer medication. Journal for the Education of Gifted Young Scientists, 8(4), 1493-1507. https://doi.org/10.17478/jegys.792830

Vidensek, N., Lim, P., Campbell, A., Carlson, C. 1990. Taxol Content in Bark, Wood, Root, Leaf, Twig, and Seedling from Several Taxus Species. J. Nat. Prod., 53(6), 1609–1610. https://doi.org/10.1021/np50072a039

Wang, S.S., Abd El-Razek, M.H., Chen, Y.G., Chien, C.T, Guh, J.H., Kuo, Y.H., Shen, Y.C. 2009. abeo-taxane diterpenoids from the Taiwanese yew Taxus sumatrana. Chemistry and Biodiversity, 6(12), 2255-2262. https://doi.org/10.1002/cbdv.200900003

Wani, M.C., Horwitz, S.B. 2014. Nature as a Remarkable Chemist: A Personal Story of the Discovery and Development of Taxol®. Anticancer Drugs, 25(5), 482–487. https://doi.org/doi:10.1097/CAD.0000000000000063

Witherup, K.M., Look, S.A., Stasko, M.W., Ghiorzi, T.J., Muschik, G.M. 1990. Taxus spp. needles containing amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation. Journal of Natural Products, 53(5), 1249–1255.